Synthesis, Characterization and the Reactivity of Transition Metal Schiff-base Complexes: Reactivity with CT-DNA
Authors:Tyler Lopez, Jennifer Wacker
Mentor:Henry Acquaye, Professor, University of Redlands
There is tremendous increase in research interest in the development of new transition metal complexes for use as chemotherapeutic agents. The upsurge in this area of research is mainly due to the success of cisplatin, cis-diamminedichloroplatinum(II) as a chemotherapeutic agent. However, because of some severe side effects associated with cisplatin, other transition metal complexes have been synthesized and investigated as possible chemotherapeutic agents. Several copper and vanadium complexes have been synthesized and some have shown promise of reactivity towards DNA. We are contributing to this area of research by synthesizing new copper and vanadium Schiff- base complexes. Schiff- base ligands with planar cyclic groups are being used to enhance intercalation between DNA base pairs. The complexes have been characterized by use of FTIR, NMR, mass spectrometry, UV–vis spectroscopy, cyclic voltammetry, elemental analysis and x-ray crystal structure determination. Initial reactivity studies with CT-DNA and plasmid DNA indicate interactions between the complexes and DNA.